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KMID : 0606920130210050343
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Biomolecules & Therapeutics
2013 Volume.21 No. 5 p.343 ~ p.348
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Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin
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Kim Bo-Ra
Lee Jee-Young
Lee Ha-Yeon
Nam Ky-Youb
Park Jong-Il
Lee Su-Min
Kim Jin-Eun
Lee Joo-Dong
Hwang Jae-Sung
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Abstract
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We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with α-melanocyte stimulating hormone (α-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent.
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KEYWORD
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Hesperidin, Melanosome transport, Rab27A, Melanophilin, Pigmented reconstructed epidermis model
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